[3:39 PM] Rifki Akbar
901503
Sigma-Aldrich

(S,R,S)-AHPC-PEG1-ALKYNE

Empform:

C28H36N4O5S

Synonyms English:

(2S,4R)-1-((S)-3,3-Dimethyl-2-(3-(prop-2-yn-1-yloxy)propanamido)butanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide; CrosslinkerE3 Ligase ligand conjugate; Protein degrader building block for PROTAC research; Template for synthesis of targeted protein degrader; VH032 conjugate

Fw: 540.67
Grouped product items
SKU Pack Size Availability Price Quantity
901503-50MG - Available to ship on April 26, 2024
IDR 14,154,000.00
Request a Bulk Order Check Availability

Properties

Properties
assay
assay range 95%
Description (S,R,S)-AHPC-PEG1-ALKYNE
format powder or crystals
MDM Code 901503-50MG
Material Number 901503
Business Unit 774
Shipping Mode COU
MRP Type PD
Local HS Code 29341000
Legacy SIGMA
Plant 6311
Sales Org 6304

Description

Application

Protein degrader builiding block (S,R,S)-AHPC-PEG1-NH2 (HCl salt) enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand and a PEGylated crosslinker with pendant amine for reactivity with a carboxyl group on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant amine, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

SAFETY INFORMATION

Signal Word

RIDADRRIDADR

WGK Germany

WGK 3

Flash Point (F)

Not applicable

Flash Point (C)

Not applicable

Target Organs

Risk Statement

Supplemental Hazard Statements

DOCUMENTATION

Certificate of Analysis View Sample COA
Certificate of Origin

TECHNICAL SERVICE

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