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    • 1,2-BIS(2-AMINOPHENOXY)ETHANE-N,N,N',N'&

    All Photos (2)

    Documents SDS COO/COA Specification Sheet
    A1076
    Sigma-Aldrich

    1,2-BIS(2-AMINOPHENOXY)ETHANE-N,N,N',N'&

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    Empform:

    C34H40N2O18

    Synonyms English:

    1,2-Bis(2-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid tetrakis(acetoxymethyl ester)

    Mdl No: MFCD00036696
    Fw: 764.68
    Pubchem Substance Id: 24890502
    CAS Number: 126150-97-8
    Grouped product items
    SKU Pack Size Availability Price Quantity
    A1076-25MG - Available to ship on June 25, 2023
    IDR6,483,000.00
    Request a Bulk Order Check Availability
    Documents SDS COO/COA Specification Sheet

    Properties

    Properties
    assay ≥
    assay range 95% (HPLC)
    Description 1,2-BIS(2-AMINOPHENOXY)ETHANE-N,N,N',N'&
    format powder
    inchi key 1S/C34H40N2O18/c1-23(37)47-19-51-31(41)15-35(16-32(42)52-20-48-24(2)38)27-9-5-7-11-29(27)45-13-14-46-30-12-8-6-10-28(30)36(17-33(43)53-21-49-25(3)39)18-34(44)54-22-50-26(4)40/h5-12H13-22H21-4H3
    indiff. to chromic acid YJIYWYAMZFVECX-UHFFFAOYSA-N
    MDM Code A1076-25MG
    Material Number A1076
    Business Unit 698
    Shipping Mode AIR
    MRP Type YP
    Local HS Code 29225090
    Legacy SIGMA
    Plant 6311
    Sales Org 6304
    CAS Number 126150-97-8

    Description

    Application

    BAPTA-AM has been used :
    • to reduce the elevation of cleaved caspase-3
    • to block cell death, inhibit ROS (reactive oxygen species) production and inhibit caspase-8 activation
    • to exclude the effect of changes in intracellular Ca2+ ([Ca2+]i) concentration during seizure induction
    • to eliminate the increase of [Ca2+]i induced by 6-hydroxydopamine (6-OHDA)

    Biochem/physiol Actions

    Selective chelator of intracellular Ca2+ stores.

    General description

    BAPTA-AM inhibits free radical-mediated toxicity, enhances apoptosis in non-neuronal cells and protects neurons from ischemic damage. It regulates ion channels and blocks neuronal Ca2+-activated K+ channel currents. BAPTA-AM maintains intracellular Ca2+ homeostasis.

    Linkage

    Membrane-permeable form of BAPTA.

    SAFETY INFORMATION

    Signal Word

    RIDADRRIDADR

    WGK Germany

    WGK 3

    Flash Point (F)

    Not applicable

    Flash Point (C)

    Not applicable

    Target Organs

    Risk Statement

    Supplemental Hazard Statements

    DOCUMENTATION

    Certificate of Analysis View Sample COA
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