A1076
Sigma-Aldrich

1,2-BIS(2-AMINOPHENOXY)ETHANE-N,N,N',N'&

Empform:

C34H40N2O18

Synonyms English:

1,2-Bis(2-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid tetrakis(acetoxymethyl ester)

Mdl No: MFCD00036696
Fw: 764.68
Pubchem Substance Id: 24890502
CAS Number: 126150-97-8
Grouped product items
SKU Pack Size Availability Price Quantity
A1076-25MG - Available to ship on March 21, 2024
IDR 6,483,000.00
Request a Bulk Order Check Availability

Properties

Properties
assay
assay range 95% (HPLC)
Description 1,2-BIS(2-AMINOPHENOXY)ETHANE-N,N,N',N'&
format powder
inchi key 1S/C34H40N2O18/c1-23(37)47-19-51-31(41)15-35(16-32(42)52-20-48-24(2)38)27-9-5-7-11-29(27)45-13-14-46-30-12-8-6-10-28(30)36(17-33(43)53-21-49-25(3)39)18-34(44)54-22-50-26(4)40/h5-12H13-22H21-4H3
indiff. to chromic acid YJIYWYAMZFVECX-UHFFFAOYSA-N
MDM Code A1076-25MG
Material Number A1076
Business Unit 698
Shipping Mode AIR
MRP Type YP
Local HS Code 29225090
Legacy SIGMA
Plant 6311
Sales Org 6304
CAS Number 126150-97-8

Description

Application

BAPTA-AM has been used :
  • to reduce the elevation of cleaved caspase-3
  • to block cell death, inhibit ROS (reactive oxygen species) production and inhibit caspase-8 activation
  • to exclude the effect of changes in intracellular Ca2+ ([Ca2+]i) concentration during seizure induction
  • to eliminate the increase of [Ca2+]i induced by 6-hydroxydopamine (6-OHDA)

Biochem/physiol Actions

Selective chelator of intracellular Ca2+ stores.

General description

BAPTA-AM inhibits free radical-mediated toxicity, enhances apoptosis in non-neuronal cells and protects neurons from ischemic damage. It regulates ion channels and blocks neuronal Ca2+-activated K+ channel currents. BAPTA-AM maintains intracellular Ca2+ homeostasis.

Linkage

Membrane-permeable form of BAPTA.

SAFETY INFORMATION

Signal Word

RIDADRRIDADR

WGK Germany

WGK 3

Flash Point (F)

Not applicable

Flash Point (C)

Not applicable

Target Organs

Risk Statement

Supplemental Hazard Statements

DOCUMENTATION

Certificate of Analysis View Sample COA
Certificate of Origin

TECHNICAL SERVICE

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