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    • ANTI-CASPASE 3, ACTIVE, DEVELOPED IN RAB

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    Documents SDS COO/COA Specification Sheet
    C8487
    Sigma-Aldrich

    ANTI-CASPASE 3, ACTIVE, DEVELOPED IN RAB

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    Synonyms English:

    Activated Caspase 3 Antibody; Activated Caspase 3 Antibody - Anti-Caspase 3, Active antibody produced in rabbit; Anti-Apopain; Anti-CPP32; Anti-Yama

    Nacres: NA.41
    Mdl No: MFCD01321906
    Grouped product items
    SKU Pack Size Availability Price Quantity
    C8487-100UL - Available to ship on November 07, 2023
    IDR7,696,000.00
    C8487-200UL - Available to ship on November 07, 2023
    IDR9,952,000.00
    C8487-25UL - Available to ship on November 07, 2023
    IDR3,227,000.00
    Request a Bulk Order Check Availability
    Documents SDS COO/COA Specification Sheet

    Properties

    Properties
    antibody form IgG fraction of antiserum
    antibody product type primary antibodies
    biological source rabbit
    clone polyclonal
    conjugate unconjugated
    Description ANTI-CASPASE 3, ACTIVE, DEVELOPED IN RAB
    form buffered aqueous solution
    gene information human ... CASP3(836)
    mouse ... Casp3(12367)
    rat ... Casp3(25402)
    MDM Code C8487-100UL
    Material Number C8487
    Business Unit 696
    Shipping Mode AIR
    MRP Type PD
    Local HS Code 30021500
    Legacy SIGMA
    Plant 6311
    Sales Org 6304

    Description

    Application

    Anti-Caspase 3, Active antibody has been used:
    • for western blotting of cytochrome c for caspase activation
    • as primary antibody in immunofluorescence staining of embryos and postnatal mice cryosections
    • in Western blot analysis of activated caspase 3
    • as a primary antibody in immunodetection of rat brain sections

    Biochem/physiol Actions

    Caspase 3 is one of the key effectors of apoptosis. It acts downstream of caspase 9 in the apoptotic pathway. During apoptosis, it gets activated by proteolytic cleavage into the 17-19 kDa (p17, p18) and 12 kDa (p12) active subunits. Any alteraion in CASP-3 in mice, causes premature lethality. It has also shown that the deletion of gene affects brain development resulting of hyperplasias and disorganized cell deployement. Clinically it is related to Huntington disease (HD). Caspase 3 brings about cell death by activating CAD (caspase activated DNAse I), an endonuclease that causes degradation of chromosomal DNA.

    Disclaimer

    Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

    General description

    Caspase-3 (CASP3) belongs to the class of cysteine proteases. CASP3 is an executioner caspase, which is cleaved and activated with the help of caspase-8 and caspase-9 initiator caspases. CASP3 is mapped to human chromosome 4q35.1.

    Immunogen

    Synthetic peptide corresponding to the cleavage site of human caspase 3 conjugated to KLH.

    Physical form

    Supplied in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

    Storage and Stability

    Store at –20 °C. For continuous use, the product may be storage, the product may be stored at 2-8 °C for up to one month. For prolonged storage, freeze in working aliquots at –20 °C. Repeated freezing and thawing, or storage in frost-free freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.

    SAFETY INFORMATION

    GHS07

    Signal Word

    Warning

    H312 - H412

    P273 - P280 - P302 + P352 + P312 - P362 + P364 - P501

    RIDADRRIDADR

    WGK Germany

    WGK 1

    Flash Point (F)

    Not applicable

    Flash Point (C)

    Not applicable

    Target Organs

    Risk Statement

    Supplemental Hazard Statements

    DOCUMENTATION

    Certificate of Analysis View Sample COA
    Lot Number
    How to enter Lot Number (COA)
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    Certificate of Origin
    Lot Number
    How to enter Lot Number (COA)
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    TECHNICAL SERVICE

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