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    • COLCHICINE

    All Photos (5)

    Documents SDS COO/COA Specification Sheet
    C9754
    Sigma-Aldrich

    COLCHICINE

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    Empform:

    C22H25NO6

    Synonyms English:

    (S)-N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)acetamide

    Nacres: NA.77
    Mdl No: MFCD00078484
    Fw: 399.44
    Pubchem Substance Id: 24278348
    CAS Number: 64-86-8
    Grouped product items
    SKU Pack Size Availability Price Quantity
    C9754-500MG - Available to ship on July 02, 2023
    IDR6,144.00
    C9754-5G - Available to ship on June 25, 2023
    IDR11,359,000.00
    C9754-1G - Available to ship on July 02, 2023
    IDR6,850.00
    C9754-100MG - Available to ship on July 02, 2023
    IDR1,600.00
    Request a Bulk Order Check Availability
    Documents SDS COO/COA Specification Sheet

    Properties

    Properties
    assay ≥
    assay range 95% (HPLC)
    coloring against scale white to yellow
    Description COLCHICINE
    format powder
    glass tube l × o.d. × i.d. human ... ABCB1(5243) CYP3A4(1576) TUBA1A(7846) TUBA1B(10376) TUBA1C(84790) TUBA3C(7278) TUBA3E(112714) TUBA4A(7277) TUBB(203068) TUBB1(81027) TUBB2A(7280) TUBB2B(347733) TUBB3(10381) TUBB4A(10382) TUBB4B(10383) TUBB6(84617) TUBB8(347688)
    mouse ... Abcb1a(18671) Abcb1b(18669)
    inchi key 1S/C22H25NO6/c1-12(24)23-16-8-6-13-10-19(27-3)21(28-4)22(29-5)20(13)14-7-9-18(26-2)17(25)11-15(14)16/h79-1116H68H21-5H3(H2324)/t16-/m0/s1
    indiff. to chromic acid IAKHMKGGTNLKSZ-INIZCTEOSA-N
    MDM Code C9754-500MG
    Material Number C9754
    Business Unit 698
    Shipping Mode AIR
    MRP Type PD
    Local HS Code 29398000
    Legacy SIGMA
    Shelf Life 61
    Plant 6311
    Sales Org 6304
    CAS Number 64-86-8

    Description

    Application

    Colchicine has been used:
    • in the in vitro sister-chromatid exchange (SCE) assay
    • to study its in vitro antiviral, antibacterial, antifungal and cytotoxic activities
    • in microtubule disruption
    • to analyse its effects on Ca2+ transients from taxol-treated cells

    Biochem/physiol Actions

    Antimitotic agent that disrupts microtubules by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway.

    Features and Benefits

    This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

    General description

    Colchicine is a secondary metabolite, which has anti-inflammatory properties. It is used to treat gout, crystal-induced joint inflammation, familial Mediterranean fever, Behçet disease, vasculitides and pericarditis. Colchicine inhibits cell division, intracellular vesicle motility, secretion of cytokines and chemokines. It is implicated in leukocyte diapedesis and lysosomal degranulation. Colchicine also blocks fibroblast proliferation and collagen transport to extracellular space.

    SAFETY INFORMATION

    GHS06,GHS08

    Signal Word

    Danger

    H300 - H340

    P202 - P264 - P270 - P280 - P301 + P310 - P405

    RIDADRRIDADR

    WGK Germany

    WGK 3

    Flash Point (F)

    Not applicable

    Flash Point (C)

    Not applicable

    Target Organs

    Risk Statement

    Supplemental Hazard Statements

    DOCUMENTATION

    Certificate of Analysis View Sample COA
    Lot Number
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    Certificate of Origin
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