C9754
Sigma-Aldrich

COLCHICINE

Empform:

C22H25NO6

Synonyms English:

(S)-N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)acetamide

Nacres: NA.77
Mdl No: MFCD00078484
Fw: 399.44
Pubchem Substance Id: 24278348
CAS Number: 64-86-8
Grouped product items
SKU Pack Size Availability Price Quantity
C9754-500MG - Available to ship on July 02, 2023
IDR6,144.00
C9754-5G - Available to ship on June 25, 2023
IDR11,359,000.00
C9754-1G - Available to ship on July 02, 2023
IDR6,850.00
C9754-100MG - Available to ship on July 02, 2023
IDR1,600.00
Request a Bulk Order Check Availability

Properties

Properties
assay
assay range 95% (HPLC)
coloring against scale white to yellow
Description COLCHICINE
format powder
glass tube l × o.d. × i.d. human ... ABCB1(5243) CYP3A4(1576) TUBA1A(7846) TUBA1B(10376) TUBA1C(84790) TUBA3C(7278) TUBA3E(112714) TUBA4A(7277) TUBB(203068) TUBB1(81027) TUBB2A(7280) TUBB2B(347733) TUBB3(10381) TUBB4A(10382) TUBB4B(10383) TUBB6(84617) TUBB8(347688)
mouse ... Abcb1a(18671) Abcb1b(18669)
inchi key 1S/C22H25NO6/c1-12(24)23-16-8-6-13-10-19(27-3)21(28-4)22(29-5)20(13)14-7-9-18(26-2)17(25)11-15(14)16/h79-1116H68H21-5H3(H2324)/t16-/m0/s1
indiff. to chromic acid IAKHMKGGTNLKSZ-INIZCTEOSA-N
MDM Code C9754-500MG
Material Number C9754
Business Unit 698
Shipping Mode AIR
MRP Type PD
Local HS Code 29398000
Legacy SIGMA
Shelf Life 61
Plant 6311
Sales Org 6304
CAS Number 64-86-8

Description

Application

Colchicine has been used:
  • in the in vitro sister-chromatid exchange (SCE) assay
  • to study its in vitro antiviral, antibacterial, antifungal and cytotoxic activities
  • in microtubule disruption
  • to analyse its effects on Ca2+ transients from taxol-treated cells

Biochem/physiol Actions

Antimitotic agent that disrupts microtubules by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway.

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

General description

Colchicine is a secondary metabolite, which has anti-inflammatory properties. It is used to treat gout, crystal-induced joint inflammation, familial Mediterranean fever, Behçet disease, vasculitides and pericarditis. Colchicine inhibits cell division, intracellular vesicle motility, secretion of cytokines and chemokines. It is implicated in leukocyte diapedesis and lysosomal degranulation. Colchicine also blocks fibroblast proliferation and collagen transport to extracellular space.

SAFETY INFORMATION

GHS06,GHS08

Signal Word

Danger

P202 - P264 - P270 - P280 - P301 + P310 - P405

RIDADRRIDADR

WGK Germany

WGK 3

Flash Point (F)

Not applicable

Flash Point (C)

Not applicable

Target Organs

Risk Statement

Supplemental Hazard Statements

DOCUMENTATION

Certificate of Analysis View Sample COA
Certificate of Origin

TECHNICAL SERVICE

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