E5389
Sigma-Aldrich

ERYTHROMYCIN BIOREAGENT, SUITABLE FOR &

Empform:

C37H67NO13

Synonyms English:

E-Mycin

Nacres: NA.76
Mdl No: MFCD00084654
Fw: 733.93
Pubchem Substance Id: 24894612
Grouped product items
SKU Pack Size Availability Price Quantity
E5389-5G - Available to ship on March 24, 2024
IDR 1,794,000.00
E5389-1G - Available to ship on March 24, 2024
IDR 619,000.00
Request a Bulk Order Check Availability

Properties

Properties
antibiotic activity spectrum Gram-negative bacteria
Description ERYTHROMYCIN BIOREAGENT, SUITABLE FOR &
form powder
gene information human ... ABCB1(5243) CYP3A4(1576) MLNR(2862)
mouse ... Abcb1a(18671) Abcb1b(18669)
impurities
inchi 0.1 
inchi key EU/mg endotoxin
indiff. to chromic acid 1S/C37H67NO13/c1-14-25-37(1045)30(41)20(4)27(39)18(2)16-35(844)32(51-34-28(40)24(38(11)12)15-19(3)47-34)21(5)29(22(6)33(43)49-25)50-26-17-36(946-13)31(42)23(7)48-26/h18-2628-323440-4244-45H14-17H21-13H3/t18-19-20+21+22-23+24+25-26+28-29+30-31+32-34+35-36-37-/m1/s1
inherent viscosity ULGZDMOVFRHVEP-RWJQBGPGSA-N
MDM Code E5389-5G
Material Number E5389
Business Unit 694
Shipping Mode AIR
MRP Type YP
Local HS Code 29415000
Legacy SIGMA
Plant 6311
Sales Org 6304

Description

Application

Erythromycin has been used:
  • as a supplement for nutrient broth medium for culturing green fluorescent protein (GFP)- expressing E. coli
  • as a model drug to determine small intestinal (SMI) microtissue viability using the MTT assay{254
  • as an antibiotic to study the treatment strategies of chronic infections

Biochem/physiol Actions

Mode of Action: Erythromycin acts by inhibiting elongation at the transpeptidation step, specifically aminoacyl translocation from the A-site to P-site by binding to the 50s subunit of the bacterial 70s rRNA complex.

Antimicrobial Spectrum: This product acts against both gram-negative and gram-positive bacteria.

Caution

This product is stable in solution at 37°C for 3 days. Stock solutions should be stored at 2-8°C.

General description

Chemical structure: macrolide

Preparation Note

This product is soluble in water at 2 mg/mL, with a 0.067% solution in water yielding a pH of 8.0-10.5. It is also soluble in ethanol at 50 mg/mL, yielding a clear, colorless to faint yellow solution. It is freely soluble in alcohol, acetone, chloroform, acetonitrile and ethyl acetate but forms salts with acids. All solutions should be protected from light.

SAFETY INFORMATION

Signal Word

RIDADRRIDADR

WGK Germany

WGK 3

Flash Point (F)

Not applicable

Flash Point (C)

Not applicable

Target Organs

Risk Statement

Supplemental Hazard Statements

DOCUMENTATION

Certificate of Analysis View Sample COA
Certificate of Origin

TECHNICAL SERVICE

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