F8257
Sigma-Aldrich

Flunarizine dihydrochloride

Empform:

C26H26F2N2 · 2HCl

Synonyms English:

1-[Bis(4-fluorophenyl)methyl]-4-(3-phenyl-2-propenyl)piperazine dihydrochloride

Nacres: NA.77
Mdl No: MFCD00058198
Fw: 477.42
Pubchem Substance Id: 24277835
CAS Number: 30484-77-6
Grouped product items
SKU Pack Size Availability Price Quantity
F8257-1G 1G Available to ship on June 25, 2023
IDR1,870,000.00
F8257-10G - Available to ship on June 25, 2023
IDR10,342,000.00
Request a Bulk Order Check Availability

Properties

Properties
assay
assay range 98% (TLC)
Description Flunarizine dihydrochloride >=98% (TLC)
inchi key 1S/C26H26F2N2.2ClH/c27-24-12-8-22(9-13-24)26(23-10-14-25(28)15-11-23)30-19-17-29(18-20-30)16-4-7-21-5-2-1-3-6-21
inherent viscosity /h1-1526H16-20H2
inlet and outlet diam. 2*1H/b7-4+
inlet cga RXKMOPXNWTYEHI-RDRKJGRWSA-N
MDM Code F8257-1G
Material Number F8257
Business Unit 698
Shipping Mode COU
MRP Type PD
Local HS Code 29335990
Legacy SIGMA
Plant 6311
Sales Org 6304
CAS Number 30484-77-6

Description

Application

Flunarizine dihydrochloride has been used to study the effect of flunarizine on epileptiform activity. It is also used to study its effect on high-potassium induced increase of intracellular free calcium.

Biochem/physiol Actions

Blocks T-type Ca2+/Na+ channels

Caution

inhibits K+-induced catecholamine release from chromaffin cells

Footnote

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Immunogen

Flunarizine has antihistamine, anticonvulsant and vestibular depressive properties. It protects endothelial cells from calcium overload-induced damage. Flunarizine is used to treat epilepsy, migraine prophylaxis, cerebral blood flow disturbances, peripheral vascular disease and vertigo.

SAFETY INFORMATION

Signal Word

Warning

P264 - P270 - P301 + P312 - P501

RIDADRRIDADR

WGK Germany

WGK 3

Flash Point (F)

Not applicable

Flash Point (C)

Not applicable

Target Organs

Risk Statement

Supplemental Hazard Statements

DOCUMENTATION

Certificate of Analysis View Sample COA
Certificate of Origin

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