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    • Flunarizine dihydrochloride

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    Documents SDS COO/COA Specification Sheet
    F8257
    Sigma-Aldrich

    Flunarizine dihydrochloride

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    Empform:

    C26H26F2N2 · 2HCl

    Synonyms English:

    1-[Bis(4-fluorophenyl)methyl]-4-(3-phenyl-2-propenyl)piperazine dihydrochloride

    Nacres: NA.77
    Mdl No: MFCD00058198
    Fw: 477.42
    Pubchem Substance Id: 24277835
    CAS Number: 30484-77-6
    Grouped product items
    SKU Pack Size Availability Price Quantity
    F8257-1G 1G Available to ship on June 25, 2023
    IDR1,870,000.00
    F8257-10G - Available to ship on June 25, 2023
    IDR10,342,000.00
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    Documents SDS COO/COA Specification Sheet

    Properties

    Properties
    assay ≥
    assay range 98% (TLC)
    Description Flunarizine dihydrochloride >=98% (TLC)
    inchi key 1S/C26H26F2N2.2ClH/c27-24-12-8-22(9-13-24)26(23-10-14-25(28)15-11-23)30-19-17-29(18-20-30)16-4-7-21-5-2-1-3-6-21
    inherent viscosity /h1-1526H16-20H2
    inlet and outlet diam. 2*1H/b7-4+
    inlet cga RXKMOPXNWTYEHI-RDRKJGRWSA-N
    MDM Code F8257-1G
    Material Number F8257
    Business Unit 698
    Shipping Mode COU
    MRP Type PD
    Local HS Code 29335990
    Legacy SIGMA
    Plant 6311
    Sales Org 6304
    CAS Number 30484-77-6

    Description

    Application

    Flunarizine dihydrochloride has been used to study the effect of flunarizine on epileptiform activity. It is also used to study its effect on high-potassium induced increase of intracellular free calcium.

    Biochem/physiol Actions

    Blocks T-type Ca2+/Na+ channels

    Caution

    inhibits K+-induced catecholamine release from chromaffin cells

    Footnote

    This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

    Immunogen

    Flunarizine has antihistamine, anticonvulsant and vestibular depressive properties. It protects endothelial cells from calcium overload-induced damage. Flunarizine is used to treat epilepsy, migraine prophylaxis, cerebral blood flow disturbances, peripheral vascular disease and vertigo.

    SAFETY INFORMATION

    GHS07

    Signal Word

    Warning

    H302

    P264 - P270 - P301 + P312 - P501

    RIDADRRIDADR

    WGK Germany

    WGK 3

    Flash Point (F)

    Not applicable

    Flash Point (C)

    Not applicable

    Target Organs

    Risk Statement

    Supplemental Hazard Statements

    DOCUMENTATION

    Certificate of Analysis View Sample COA
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