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H8916
Sigma-Aldrich

Tumor Necrosis Factor-alpha human

Nacres: human
CAS Number: 94948-59-1
Grouped product items
SKU Pack Size Availability Price Quantity
H8916-10UG 10UG Available to ship on May 18, 2024
IDR 3,905,000.00
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Properties

Properties
assay
assay range 95% (SDS-PAGE)
blade diam. human
Description Tumor Necrosis Factor-alpha human TNF-alpha, recombinant, expressed in HEK 293 cells, suitable for cell culture
format lyophilized powder
glass tube l × o.d. × i.d. human ... TNF(7124)
inchi
inchi key
indiff. to chromic acid EU/μ
inherent viscosity g
MDM Code H8916-10UG
Material Number H8916
Business Unit 694
Shipping Mode COU
MRP Type PD
Local HS Code 30021500
Legacy SIGMA
Plant 6311
Sales Org 6304
CAS Number 94948-59-1

Description

Analysis Note

The specific activity was determined by the dose-dependent cytotoxity of the TNF alpha sensitive cell line L-929 in the presence of actinomycin D.

Application

Tumor Necrosis Factor-α

Biochem/physiol Actions

(TNF-α

Caution

) human has been used
  • In induction of netting neutrophils by anti-neutrophil cytoplasmic antibody and to study its effect on platelet activation and formation of monomeric C-reactive protein.
  • To study the effect of TNF-α

Cell Line Description

on miR-221 and fractalkine expression.
  • To induce inflammatory cell responses.
  • In NF-κ
  • Cell Line Origin

    B luciferase reporter assay.

    Chem/Phys Resistance

    Tumor Necrosis Factor-α (TNF-α) is a potent pro-inflammatory cytokine that plays a role in the rheumatoid arthritis pathology, psoriatic arthritis (PsA) and psoriasis. It stimulates interleukins IL-1 and IL-6. Polymorphism in the TNF-α gene is associated with destructive arthropathy in PsA. The post-translational modifications in TNF-a is crucial for its functionality.

    Other Notes

    The TNFα

    Packaging

    (tumor necrosis factor α

    Physical form

    ) gene is mapped to human chromosome 6p21.33. TNFα

    Physical properties

    is a member of TNF superfamily. TNF-α

    Preparation Note

    has a palmitoyl group in the cysteine residue and is phosphorylated in the transmembrane region serine residue.

    Serological Profile

    Tumor Necrosis Factor-α (TNF-α) is expressed in human HEK 293 cells and has been shown to be predominantly a glycosylated, non-covalently linked homotrimer with a molecular mass of 51 kDa (gel filtration). Production in human 293 cells offers authentic glycosylation. Glycosylation contributes to stability in cell growth media and other applications.

    SAFETY INFORMATION

    Signal Word

    RIDADRRIDADR

    WGK Germany

    WGK 2

    Flash Point (F)

    Not applicable

    Flash Point (C)

    Not applicable

    Target Organs

    Risk Statement

    Supplemental Hazard Statements

    DOCUMENTATION

    Certificate of Analysis View Sample COA
    Certificate of Origin

    TECHNICAL SERVICE

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