Imidazole for molecular biology, >=99% (titration)
format
DNase RNase and protease none detected
fragrance allergen
crystalline powder
graduations and accuracy measuring range
for molecular biology
indiff. to chromic acid
1S/C3H4N2/c1-2-5-3-4-1/h1-3H(H45)
inherent viscosity
RAXXELZNTBOGNW-UHFFFAOYSA-N
MDM Code
I5513-5G
Material Number
I5513
Business Unit
499
Shipping Mode
AIR
MRP Type
PD
Local HS Code
29332900
Legacy
SIGMA
Plant
6311
Sales Org
6304
Description
Application
Excellent for buffers in the range of pH 6.2-7.8
Biochem/physiol Actions
Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division. It also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).
General description
Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.