[3:39 PM] Rifki Akbar
L9393
Sigma-Aldrich

ANTI-LAMININ ANTIBODY PRODUCED IN&

Synonyms English:

Laminin Antibody

Nacres: NA.41
Mdl No: MFCD00162586
Grouped product items
SKU Pack Size Availability Price Quantity
L9393-.2ML - Available to ship on May 02, 2024
IDR 9,952,000.00
L9393-.5ML - Available to ship on May 02, 2024
IDR 19,902,000.00
L9393-100UL - Available to ship on May 02, 2024
IDR 8,878,000.00
Request a Bulk Order Check Availability

Properties

Properties
antibody form affinity isolated antibody
antibody product type primary antibodies
applications research pathology
biological source rabbit
clone polyclonal
concentration 0.5 
concentricity mg/mL
connections o.d. unconjugated
Description ANTI-LAMININ ANTIBODY PRODUCED IN&
ensembl | human accession no. independent
Learn more about Antibody Enhanced Validation
format buffered aqueous solution
glass tube l × o.d. × i.d. human ... LAMA1(284217)
mouse ... Lama1(16772)
MDM Code L9393-.2ML
Material Number L9393
Business Unit 696
Shipping Mode AIR
MRP Type PD
Local HS Code 30021500
Legacy SIGMA
Plant 6311
Sales Org 6304

Description

Application

Anti-Laminin antibody has been used in immunohistochemical staining and immunohistochemistry.

Biochem/physiol Actions

LAMA1 (laminin subunit α 1) is involved in several diseases like cancer, infections, inflammatory diseases and autoimmune disorders. Mutations in LAMA1 result in cerebellar dysplasia and cysts with and without retinal dystrophy. LAMA1 is also essential in the assembly of basement membrane and early growth of embryo.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Laminin is a ubiquitous non-collagenous connective tissue glycoprotein that is a major constituent of basement membranes. Laminins are extracellular matrix proteins. The LAMA1 (laminin subunit α 1) gene is mapped to human chromosome 18p11. The antibody is isolated from antiserum by immunospecific methods of purification. Antigen specific isolation removes essentially all rabbit serum proteins, including immunoglobulins that do not specifically bind to laminin.

Immunogen

Laminin isolated from the basement membrane of Englebreth Holm-Swarm (EHS) mouse sarcoma.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% BSA and 15 mM sodium azide.

Specificity

Specificity of the anti-laminin antibodies is determined by indirect immunofluorescent labeling of formalin-fixed, paraffin-embedded human or animal tissue sections, and by dot blot immunoassay. By indirect immunofluorescence the antibody demonstrates specific basement membrane staining of enzymatically unmasked human and animal tissue. In the dot blot immunoassay the rabbit anti-laminin antibody reacts with laminin but not with fibronectin, vitronectin, collagen IV, or chondroitin sulfate types A, B, and C. The affinity isolated antibody to laminin will react with laminin of human, mammal, avian, reptilian, and amphibian sources.

Storage and Stability

For continuous use, store at 2-8 °C for up to one month. For extended storage, the solution may be frozen in working aliquots. Repeated freezing and thawing, or storage in \frost-free\ freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify by centrifugation before use.

SAFETY INFORMATION

Signal Word

RIDADRRIDADR

WGK Germany

WGK 2

Flash Point (F)

Not applicable

Flash Point (C)

Not applicable

Target Organs

Risk Statement

Supplemental Hazard Statements

DOCUMENTATION

Certificate of Analysis View Sample COA
Certificate of Origin

TECHNICAL SERVICE

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