Search
Advanced Search
ID
ENGLISH
Language
CHANGE LANGUAGE
Menu
Location
ID
Language
ENGLISH
Language
CHANGE LANGUAGE
Account
Cart 0
    • Compare ()
  • Quick Order
    • (+/-)-NICOTINE

    All Photos (2)

    Documents SDS COO/COA Specification Sheet
    N0267
    Sigma-Aldrich

    (+/-)-NICOTINE

    Write a review

    Empform:

    C10H14N2

    Mdl No: MFCD00065370
    Fw: 162.23
    Pubchem Substance Id: 24897418
    CAS Number: 22083-74-5
    Grouped product items
    SKU Pack Size Availability Price Quantity
    N0267-100MG 100mg Available to ship on October 21, 2023
    IDR2,984,000.00
    N0267-1G - Available to ship on October 21, 2023
    IDR17,852,000.00
    N0267-500MG - Available to ship on October 21, 2023
    IDR10,106,000.00
    Request a Bulk Order Check Availability
    Documents SDS COO/COA Specification Sheet

    Properties

    Properties
    assay ≥
    assay range 99% (TLC)
    coloring against scale yellow
    density of sugar measuring range 1.02 
    depth g/mL 
    depth × h × w at 25 
    depth × overall h ?C (lit.)
    frame size liquid
    gloss human ... CHRNA2(1135) CHRNA3(1136) CHRNA4(1137)
    rat ... Chrna3(25101) Chrna4(25590) Chrna7(25302)
    inlet and outlet diam. 1S/C10H14N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h246810H357H21H3
    inlet and outlet nptm × nptm SNICXCGAKADSCV-UHFFFAOYSA-N
    MDM Code N0267-100MG
    Material Number N0267
    Business Unit 698
    Shipping Mode AIR
    MRP Type PD
    Local HS Code 29397900
    Legacy SIGMA
    Plant 6311
    Sales Org 6304
    CAS Number 22083-74-5

    Description

    Application

    (±)-Nicotine has been used:
    • as a supplement of high-glucose Dulbecco′s modified Eagle′s medium, to test its effect on mesenchymal stem cells
    • as a standard for the determination of nicotine concentration using phase high-pressure liquid chromatography
    • as a test compound to study its effects on fibril formation

    Biochem/physiol Actions

    (±)-Nicotine is a tertiary amine compound that is predominantly present in tobacco. It binds to the nicotinic cholinergic receptors of the brain, autonomic ganglia and neuromuscular junction. Nicotine allosterically regulates a number of biological events such as production of growth hormone, dopamine, adrenocorticotropic hormone and prolactin. Nicotine absorption across biological membranes is pH sensitive, which alters its ionization state. Absorption of nicotine is shown to be higher at alkaline pH, when it remains unionized. Nicotine metabolism occurs extensively in the liver and it can cross placenta.

    Other Notes

    Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. N0267.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

    SAFETY INFORMATION

    GHS06,GHS09

    Signal Word

    Danger

    H301 - H310 - H411

    P262 - P264 - P273 - P280 - P301 + P310 - P302 + P352 + P310

    RIDADRRIDADR

    WGK Germany

    WGK 3

    Flash Point (F)

    213.8 °F - closed cup

    Flash Point (C)

    101 °C - closed cup

    Target Organs

    Risk Statement

    Supplemental Hazard Statements

    DOCUMENTATION

    Certificate of Analysis View Sample COA
    Lot Number
    How to enter Lot Number (COA)
    Search
    Certificate of Origin
    Lot Number
    How to enter Lot Number (COA)
    Search

    More Documents

    TECHNICAL SERVICE

    Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.