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    • Phorbol 12-myristate 13-acetate

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    Documents SDS COO/COA Specification Sheet
    P8139
    Sigma-Aldrich

    Phorbol 12-myristate 13-acetate

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    Empform:

    C36H56O8

    Synonyms English:

    12-O-Tetradecanoylphorbol 13-acetate; 4β,9α,12β,13α,20-Pentahydroxytiglia-1,6-dien-3-one 12-tetradecanoate 13-acetate; PMA; TPA

    Nacres: NA.77
    Mdl No: MFCD00036736
    Fw: 616.83
    Pubchem Substance Id: 24278653
    CAS Number: 16561-29-8
    Grouped product items
    SKU Pack Size Availability Price Quantity
    P8139-10MG 10MG Available to ship on June 25, 2023
    IDR14,856,000.00
    P8139-1MG 1X1mg Available to ship on June 25, 2023
    IDR2,790,000.00
    P8139-25MG - Available to ship on June 25, 2023
    IDR25,879,000.00
    P8139-5MG - Available to ship on June 25, 2023
    IDR6,649,000.00
    Request a Bulk Order Check Availability
    Documents SDS COO/COA Specification Sheet

    Properties

    Properties
    assay ≥
    assay range 99% (TLC)
    Description Phorbol 12-myristate 13-acetate >=99% (TLC), film or powder
    format film or powder
    inchi key 1S/C36H56O8/c1-7-8-9-10-11-12-13-14-15-16-17-18-29(39)43-32-24(3)35(42)27(30-33(56)36(3032)44-25(4)38)20-26(22-37)21-34(41)28(35)19-23(2)31(34)40/h19-202427-2830323741-42H7-1821-22H21-6H3/t24-27+28-30-32-34-35-36-/m1/s1
    indiff. to chromic acid PHEDXBVPIONUQT-RGYGYFBISA-N
    MDM Code P8139-10MG
    Material Number P8139
    Business Unit 698
    Shipping Mode AIR
    MRP Type PD
    Local HS Code 29153990
    Legacy SIGMA
    Plant 6311
    Sales Org 6304
    CAS Number 16561-29-8

    Description

    Application

    Phorbol 12-myristate 13-acetate has been used for the stimulation of various cells including spleen cells, quiescent lymphocytes and fetal thymocytes. It has also been used for the activation of PKC (protein kinase C) in cells.

    Biochem/physiol Actions

    Potent tumor promoter

    Caution

    activates protein kinase C in vivo and in vitro.

    Cell Line Description

    Photosensitive

    Footnote

    This compound is featured on the PKC page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

    Immunogen

    Phorbol 12-myristate 13-acetate is a phorbol ester. It works as a tumor promoter and is involved in gene transcription, cell growth, differentiation, programmed cell death, immune pathway and receptor desensitization via protein kinase C (PKC) signaling pathways. Phorbol 12-myristate 13-acetate is also a model agent to study growth factors-, hormones-, and cytokines-mediated regulation of cellular growth and differentiation.

    SAFETY INFORMATION

    GHS05,GHS06,GHS08

    Signal Word

    Danger

    H300 + H310 + H330 - H314 - H317 - H334 - H351

    P202 - P260 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338

    RIDADRRIDADR

    WGK Germany

    WGK 3

    Flash Point (F)

    Flash Point (C)

    Target Organs

    Risk Statement

    Supplemental Hazard Statements

    DOCUMENTATION

    Certificate of Analysis View Sample COA
    Lot Number
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    Certificate of Origin
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