P8139
Sigma-Aldrich

Phorbol 12-myristate 13-acetate

Empform:

C36H56O8

Synonyms English:

12-O-Tetradecanoylphorbol 13-acetate; 4β,9α,12β,13α,20-Pentahydroxytiglia-1,6-dien-3-one 12-tetradecanoate 13-acetate; PMA; TPA

Nacres: NA.77
Mdl No: MFCD00036736
Fw: 616.83
Pubchem Substance Id: 24278653
CAS Number: 16561-29-8
Grouped product items
SKU Pack Size Availability Price Quantity
P8139-10MG 10MG Available to ship on March 21, 2024
IDR 14,856,000.00
P8139-1MG 1X1mg Available to ship on March 21, 2024
IDR 2,790,000.00
P8139-25MG - Available to ship on March 21, 2024
IDR 25,879,000.00
P8139-5MG - Available to ship on March 21, 2024
IDR 6,649,000.00
Request a Bulk Order Check Availability

Properties

Properties
assay
assay range 99% (TLC)
Description Phorbol 12-myristate 13-acetate >=99% (TLC), film or powder
format film or powder
inchi key 1S/C36H56O8/c1-7-8-9-10-11-12-13-14-15-16-17-18-29(39)43-32-24(3)35(42)27(30-33(56)36(3032)44-25(4)38)20-26(22-37)21-34(41)28(35)19-23(2)31(34)40/h19-202427-2830323741-42H7-1821-22H21-6H3/t24-27+28-30-32-34-35-36-/m1/s1
indiff. to chromic acid PHEDXBVPIONUQT-RGYGYFBISA-N
MDM Code P8139-10MG
Material Number P8139
Business Unit 698
Shipping Mode AIR
MRP Type PD
Local HS Code 29153990
Legacy SIGMA
Plant 6311
Sales Org 6304
CAS Number 16561-29-8

Description

Application

Phorbol 12-myristate 13-acetate has been used for the stimulation of various cells including spleen cells, quiescent lymphocytes and fetal thymocytes. It has also been used for the activation of PKC (protein kinase C) in cells.

Biochem/physiol Actions

Potent tumor promoter

Caution

activates protein kinase C in vivo and in vitro.

Cell Line Description

Photosensitive

Footnote

This compound is featured on the PKC page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Immunogen

Phorbol 12-myristate 13-acetate is a phorbol ester. It works as a tumor promoter and is involved in gene transcription, cell growth, differentiation, programmed cell death, immune pathway and receptor desensitization via protein kinase C (PKC) signaling pathways. Phorbol 12-myristate 13-acetate is also a model agent to study growth factors-, hormones-, and cytokines-mediated regulation of cellular growth and differentiation.

SAFETY INFORMATION

GHS05,GHS06,GHS08

Signal Word

Danger

H300 + H310 + H330 - H314 - H317 - H334 - H351

P202 - P260 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338

RIDADRRIDADR

WGK Germany

WGK 3

Flash Point (F)

Flash Point (C)

Target Organs

Risk Statement

Supplemental Hazard Statements

DOCUMENTATION

Certificate of Analysis View Sample COA
Certificate of Origin

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