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    • METFORMIN HYDROCHLORIDE

    All Photos (1)

    Documents SDS COO/COA Specification Sheet
    PHR1084
    Supelco

    METFORMIN HYDROCHLORIDE

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    Linear Formula:

    NH2C(=NH)NHC(=NH)N(CH3)2 · HCl

    Empform:

    C4H11N5 · HCl

    Synonyms English:

    1,1-Dimethylbiguanide hydrochloride; Metformin

    Nacres: NA.24
    Mdl No: MFCD00012582
    Fw: 165.62
    Pubchem Substance Id: 329823106
    Grouped product items
    SKU Pack Size Availability Price Quantity
    PHR1084-500MG - Available to ship on June 29, 2023
    IDR3,056,900.00
    Request a Bulk Order Check Availability
    Documents SDS COO/COA Specification Sheet

    Properties

    Properties
    agency traceable to Ph. Eur. M0605000
    applications pharmaceutical (small molecule)
    cofa current certificate can be downloaded
    Description METFORMIN HYDROCHLORIDE
    format neat
    grade certified reference material
    inchi 1S/C4H11N5.ClH/c1-9(2)4(7)8-3(5)6
    inchi key /h1-2H3(H55678)
    indiff. to chromic acid 1H
    inherent viscosity OETHQSJEHLVLGH-UHFFFAOYSA-N
    MDM Code PHR1084-500MG
    Material Number PHR1084
    Business Unit 531
    Shipping Mode COU
    MRP Type PD
    Legacy SIGMA
    Plant 6311
    Sales Org 6304

    Description

    Analysis Note

    These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

    Application

    Metformin hydrochloride may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using different chromatography techniques.

    Biochem/physiol Actions

    Metformin is an antidiabetic agent that reduces blood glucose levels and improves insulin sensitivity. Its metabolic effects, including the inhibition of hepatic gluconeogenesis, are mediated at least in part by activation of the LKB1-AMPK (AMP-activated protein kinase) pathway. Activation of this pathway also appears to be involved in the antiproliferative and proapoptotic actions of metformin in cancer cell lines.

    Footnote

    To see an example of a Certificate of Analysis for this material enter LRAB3694 in the slot below. This is an example certificate only and may not be the lot that you receive.

    General description

    Metformin is a biguanide hypoglycaemic agent and an oral antidiabetic medication widely used in the treatment of type 2 diabetes. It is effective in glycemic control and decreases the intestinal absorption of glucose, without the problem of serious lactic acidosis.

    Other Notes

    This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

    SAFETY INFORMATION

    GHS07

    Signal Word

    Warning

    H302

    P301 + P312 + P330

    RIDADRRIDADR

    WGK Germany

    WGK 3

    Flash Point (F)

    Flash Point (C)

    Target Organs

    Risk Statement

    Supplemental Hazard Statements

    DOCUMENTATION

    Certificate of Analysis View Sample COA
    Lot Number
    How to enter Lot Number (COA)
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    Certificate of Origin
    Lot Number
    How to enter Lot Number (COA)
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