For years, Novabiochem® peptide synthesis reagents have set the gold standard for quality and reliability. The quality of reagents is critical to the scientific credibility of results obtained with synthetic peptides. Small, almost trivial, differences in purity of the starting reagents can greatly affect the microheterogeneity of the product peptide. For example, building blocks with only 99.5% optical purity can theoretically only produce 78% of the target 50mer, whereas building blocks with 99.8% optical purity rise to 90%. The purified products from both syntheses can look homogeneous by HPLC, however the peptide obtained using the 99.5% optically pure building blocks will only contain at maximum 78% of the target: the diastereomeric by-products will be hiding under the product peak as they are inseparable and are of course undetectable by MS.

It is for this reason we strive to make our 20 standard Fmoc-amino acids amongst the highest quality available on the market. Most importantly, we analyze for known microimpurities, which could produce inseparable and undetectable impurities in the final peptide product:

• Majority specified to ≥ 99.00% HPLC purity and ≥ 99.80% enantiomeric purity
• Analyzed using internal standards for β-alanine-related impurities, dipeptides and unprotected amino acids to ensure these crucial peptidic impurities are not hidden under the main product peak
• Very low acetate and ethyl acetate content to ensure formation of capped peptides is negligible and to promote long-term storage of these products

With the capability to offer large batches, we support your growth every step of the way, from R&D to scaled-up production across the globe. Get the exact quality and quantity you need for:

• Peptide synthesis
• High-throughput organic chemistry
• Labeled peptides
• Custom-manufactured products