R4408
Sigma-Aldrich

Chloramphenicol

Synonyms English:

D-(-)-threo-2,2-Dichloro-N-[β-hydroxy-α−(hydroxymethyl)-β-(4-nitrophenyl)ethyl]acetamide; D-(-)-threo-2-Dichloroacetamido-1-(4-nitrophenyl)-1,3-propanediol; D-threo-2,2-Dichloro-N-[β-hydroxy-α-(hydroxymethyl)-4-nitrophenethyl]acetamide

Nacres: NA.85
Grouped product items
SKU Pack Size Availability Price Quantity
R4408-10ML 10ML Available to ship on June 25, 2023
IDR1,716,000.00
Request a Bulk Order Check Availability

Properties

Properties
antibiotic activity spectrum Gram-negative bacteria
assay
assay range 98% (HPLC)
concentricity 100 
concentricity × camber mg/mL in ethanol: isopropanol (95:5)
Description Chloramphenicol Ready Made Solution, 100 mg/mL in ethanol: isopropanol (95:5), >=98% (HPLC)
fragrance allergen solution
MDM Code R4408-10ML
Material Number R4408
Business Unit 777
Shipping Mode AIR
MRP Type PD
Local HS Code 38229090
Legacy SIGMA
Plant 6311
Sales Org 6304

Description

Application

Chloramphenicol is a synthetic antibiotic, isolated from strains of Streptomyces venezuelae. It is often used for bacterial selection in molecular biology applications at 10-20 μg/mL and as a selection agent for transformed cells containing chloramphenicol reistance genes.

Biochem/physiol Actions

Mode of Action: Chloramphenicol inhibits bacterial protein synthesis by blocking the peptidyl transferase step by binding to the 50S ribosomal subunit and preventing attachment of aminoacyl tRNA to the ribosome. It also inhibits mitochondrial and chloroplast protein synthesis and ribosomal formation of (p)ppGpp, de-pressing rRNA transcription.

Mode of Resistance: Use of chloramphenicol acetyltransferase will acetylate the product and inactivate it.

Antimicrobial Spectrum: This is a broad spectrum antibiotic against gram-positive and gram-negative bacteria, and is used mainly for ophthalmic and veterinary purposes.

Other Notes

Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.Storage class (TRGS 510): Flammable liquids\)

Packaging

10ml

Preparation Note

This product is a ready made solution of 100 mg/mL in ethanol:isopropanol (95:5). It is shipped in dry ice and stored at -20°C.

SAFETY INFORMATION

GHS02,GHS05,GHS08

Signal Word

Danger

H225 - H318 - H351 - H361fd

P202 - P210 - P233 - P280 - P305 + P351 + P338 - P308 + P313

RIDADRRIDADR

WGK Germany

WGK 3

Flash Point (F)

57.2 °F - closed cup

Flash Point (C)

14.0 °C - closed cup

Target Organs

Risk Statement

Supplemental Hazard Statements

DOCUMENTATION

Certificate of Analysis View Sample COA
Certificate of Origin

TECHNICAL SERVICE

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