Human CSF1R / Macrophage Colony-stimulating Factor 1 Receptor ELISA Kit
determination of p-n
colorimetric
glass tube o.d. × l
human ... CSF1R(1436)
MDM Code
RAB0711-1KT
Material Number
RAB0711
Business Unit
759
Shipping Mode
AIR
MRP Type
PD
Local HS Code
30021500
Legacy
SIGMA
Plant
6311
Sales Org
6304
CAS Number
0
Description
Application
For research use only. Not for use in diagnostic procedures. Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)
Biochem/physiol Actions
CSF1R (colony stimulating factor 1 receptor) acts as a receptor for CSF1 and regulates monocyte and macrophage functioning. The protein and its ligand are linked to poor prognosis in patients with solid tumors and in patients with female reproductive cancers. In breast cancers, with decreased claudin levels, this protein regulates the switch between proliferative and invasive state of the tumor, acting downstream of TGFβ (tumor growth factor β). Haploinsufficiency in this receptor might lead to aberration of microglial function, which might be a contributor to the pathogenesis of hereditary diffuse leukoencephalopathy with spheroids (HDLS).
General description
CSF1R (colony stimulating factor 1 receptor) is a member of the platelet-derived growth factor (PDGF) family of proteins and is a type III RTK (receptor tyrosine kinase). CSF1R is composed of five immunoglobulin (Ig)-like domains, a transmembrane region, a juxtamembrane domain and kinase insert domain (KID) intersecting the kinase domain.
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