[3:39 PM] Rifki Akbar
S0130
Sigma-Aldrich

STREPTOZOTOCIN MIXED ANOMERS

Empform:

C8H15N3O7

Synonyms English:

N-(Methylnitrosocarbamoyl)-α

Nacres: NA.77
Mdl No: MFCD00006607
Fw: 265.22
Pubchem Substance Id: 57654595
CAS Number: 18883-66-4
Grouped product items
SKU Pack Size Availability Price Quantity
S0130-1G - Available to ship on April 26, 2024
IDR 8,434,000.00
S0130-5G - Available to ship on April 26, 2024
IDR 37,962,000.00
S0130-50MG - Available to ship on May 03, 2024
IDR 2,260.00
S0130-500MG - Available to ship on May 03, 2024
IDR 10,870.00
S0130-100MG - Available to ship on May 03, 2024
IDR 4,060.00
Request a Bulk Order Check Availability

Properties

Properties
antibiotic activity spectrum neoplastics
assay
assay range 75% α
astm d 2162 -anomer basis
column capacity white to light yellow
Description STREPTOZOTOCIN MIXED ANOMERS
fragrance allergen powder
indiff. to chromic acid 1S/C8H15N3O7/c1-11(10-17)8(16)9-4-6(14)5(13)3(2-12)18-7(4)15/h3-712-15H2H21H3(H916)/t3-4-5-6-7+/m1/s1
inherent viscosity ZSJLQEPLLKMAKR-GKHCUFPYSA-N
MDM Code S0130-1G
Material Number S0130
Business Unit 698
Shipping Mode AIR
MRP Type YP
Local HS Code 29419000
Legacy SIGMA
Plant 6311
Sales Org 6304
CAS Number 18883-66-4

Description

Application

Streptozocin or streptozotocin is used to induce type 1 diabetes for medical research.

Biochem/physiol Actions

An N-nitroso-containing compound that acts as a nitric oxide donor in pancreatic islets; induces death of insulin-secreting cells, producing an animal model of diabetes. Potent DNA methylating agent that induces chromosomal breakage. Cytotoxic to neuroendocrine tumor cell lines that express the GLUT2 glucose transporter.

Features and Benefits

This compound was developed by Pfizer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

General description

Streptozocin or streptozotocin, is obtained from Streptomyces achromogenes. Streptozotocin, a glucosamine-nitrosourea, is a DNA alkylating agent that enters cells exclusively via the GLUT2 glucose transport protein. Streptozocin, a diabetagen, is especially toxic to pancreatic islet insulin-producing β-cells. It is toxic to GLUT2 positive neuroendocrine tumor cells.

Other Notes

Mixed anomers

SAFETY INFORMATION

GHS02,GHS08

Signal Word

Warning

H228 - H341 - H351

P201 - P202 - P210 - P240 - P241 - P308 + P313

RIDADRRIDADR

WGK Germany

WGK 3

Flash Point (F)

Not applicable

Flash Point (C)

Not applicable

Target Organs

Risk Statement

Supplemental Hazard Statements

DOCUMENTATION

Certificate of Analysis View Sample COA
Certificate of Origin

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