S6501
Sigma-Aldrich

STREPTOMYCIN SULFATE

Linear Formula:

C21H39N7O12 · 1.5 H2SO4

Empform:

C21H39N7O12 · 1.5H2O4S

Nacres: NA.76
Mdl No: MFCD00037023
Fw: 728.69
Pubchem Substance Id: 24899705
Grouped product items
SKU Pack Size Availability Price Quantity
S6501-5G - Available to ship on April 09, 2024
IDR 2,023.00
S6501-100G - Available to ship on April 02, 2024
IDR 2,039,000.00
S6501-1KG - Available to ship on April 02, 2024
IDR 15,150,000.00
S6501-50G - Available to ship on April 02, 2024
IDR 1,364,000.00
S6501-25G - Available to ship on April 09, 2024
IDR 1,750.00
Request a Bulk Order Check Availability

Properties

Properties
antibiotic activity spectrum Gram-negative bacteria
biological source Streptomyces griseus
Description STREPTOMYCIN SULFATE
form powder
inchi 1S/2C21H39N7O12.3H2O4S/c2*1-5-21(364-30)16(40-17-9(26-2)13(34)10(31)6(3-29)38-17)18(37-5)39-15-8(28-20(24)25)11(32)7(27-19(22)23)12(33)14(15)35
inchi key 3*1-5(23)4/h2*4-18262931-36H3H21-2H3(H4222327)(H4242528)
indiff. to chromic acid 3*(H21234)/t2*5-6-7-8+9-10-11-12+13-14-15-16-17-18-21+
inlet and outlet nptm × nptm /m00.../s1
inlet and outlet size QTENRWWVYAAPBI-YZTFXSNBSA-N
MDM Code S6501-5G
Material Number S6501
Business Unit 777
Shipping Mode AIR
MRP Type PD
Local HS Code 29412000
Legacy SIGMA
Shelf Life 61
Plant 6311
Sales Org 6304

Description

Application

Streptomycin is used to study mechanisms of streptomycin resistance and is often used together with penicillin and other agents to inhibit bacterial contamination in cell culture applications. It is recommended for use in molecular biology applications at 25-50μg/mL, in cell culture applications at 100 mg/L and in embryo culture at 50 mg/L.

Biochem/physiol Actions

Mode of Action: Streptomycin acts by inhibiting prokaryote protein synthesis by binding to the S12 protein of the 30S ribosomal subunit, thus preventing the transition from imitation complex to chain-elongating ribosome. This causes miscoding or inhibits initiation.

Mode of Resistance: A mutation in rpsL, a gene for S12 ribosomal protein, prevents binding of streptomycin to the ribosome. An aminoglycoside phosphotransferase also inactivates streptomycin.

Antimicrobial spectrum: Streptomycin acts against gram-negative and gram-positive bacteria.

Caution

Solutions can be stored at 2-8°C for up to a month or at -20°C for more extended periods. At 37°C, solutions are stable for three days.

General description

Chemical structure: aminoglycoside

Other Notes

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place

Preparation Note

Stock solutions should be prepared directly in the vial with sterile water at concentrations between 20-25 mg/mL.

SAFETY INFORMATION

GHS07,GHS08

Signal Word

Warning

H302 - H361fd

P202 - P264 - P270 - P280 - P301 + P312 - P308 + P313

RIDADRRIDADR

WGK Germany

WGK 3

Flash Point (F)

Not applicable

Flash Point (C)

Not applicable

Target Organs

Risk Statement

Supplemental Hazard Statements

DOCUMENTATION

Certificate of Analysis View Sample COA
Certificate of Origin

TECHNICAL SERVICE

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