Description
Activin A has been used:
- to induce differentiation of embryonic stem cells to pancreatic β
cellsin the induction of bone marrow-derived mesenchymal stem cells to insulin-producing cellsto induce endoderm differentiation from human embryonic stem cellsas a component of β
Activins interact with Type I and Type II serine/threonine kinases to signal to SMAD proteins to regulate a variety of functions, including cell proliferation, differentiation, wound healing, apoptosis, metabolism, etc. Activin A is a homodimer of two β A chains and is not biologically active until the N terminal propeptide is cleaved from each chain. Activin A is involved in mesoderm formation and hematopoietic development.
Recombinant mouse Activin A is lyophilized with 0.02% TFA.
Centrifuge the vial prior to opening.
Centrifuge vial before opening. When reconstituting the product, gently pipet and wash down the sides of the vial to ensure full recovery of the protein into solution. It is recommended to reconstitute the lyophilized product with sterile water, which can then be further diluted to other aqueous solutions.