W222402
Sigma-Aldrich

CAFFEINE, ANHYDROUS, 99%, FCC, FG

Empform:

C8H10N4O2

Synonyms English:

1,3,7-Trimethylxanthine

Nacres: NA.21
Mdl No: MFCD00005758
Fw: 194.19
Fema No: 2224
Pubchem Substance Id: 24900939
CAS Number: 58-08-2
Grouped product items
SKU Pack Size Availability Price Quantity
W222402-1KG-K - Available to ship on March 24, 2024
IDR 1,280,000.00
W222402-SAMPLE-K - Available to ship on March 24, 2024
IDR 1,027,000.00
W222402-10KG-K - Available to ship on April 10, 2024
IDR 18,515,600.00
Request a Bulk Order Check Availability

Properties

Properties
applications flavors and fragrances
assay 99%
biological source synthetic
Description CAFFEINE, ANHYDROUS, 99%, FCC, FG
documentation see Safety &
does not contain Documentation for available documents
foreign activity no known allergens
format powder
glass tube l × o.d. × i.d. human ... ADORA1(134) ADORA2B(136) ADORA3(140) PDE4B(5142)
mouse ... Adora2b(11541)
rat ... Adora1(29290) Adora2a(25369)
gradient analysis FG
inchi key 1S/C8H10N4O2/c1-10-4-9-6-5(10)7(13)12(3)8(14)11(6)2/h4H1-3H3
indiff. to chromic acid RYYVLZVUVIJVGH-UHFFFAOYSA-N
MDM Code W222402-1KG-K
Material Number W222402
Business Unit 054
Shipping Mode AIR
MRP Type YP
Local HS Code 29393000
Legacy SIGMA
Plant 6311
Sales Org 6304
CAS Number 58-08-2

Description

Application

Caffeine (1,3,7-Trimethylxanthine) has been used in a study to determine the benefits of co-ingestion of carbohydrate and caffeine on rugby performance.

Biochem/physiol Actions

A central nervous system stimulant believed to act through adenosine receptors and monoamine neurotransmitters. It is an adenosine receptor antagonist and adenosine 3′,5′-cyclic monophosphate (cAMP) phosphodiesterase inhibitor. Thus, levels of cAMP increase in cells following treatment with caffeine. It has been reported to affect cellular calcium levels, releasing calcium from intracellular stores. It overrides the cell cycle effects of various chemicals such as protease inhibitors, preventing apoptosis; and it has been shown to inhibit cellular DNA repair mechanisms.

General description

Caffeine is an addictive psychoactive compound, consumed mostly in the form of brewed coffee, instant coffee, tea and caffeinated soft drinks. Caffeine is reported to be an allergen and causes anaphylaxis. It is added to common analgesics such as paracetamol, ibuprofen and aspirin for enhancing their analgesic efficacy. It is a plant-derived drug and has been detected in low doses in the floral nectar and pollen of Citrus. Determination of caffeine in beverages by square-wave voltammetry using Nafion-ruthenium oxide pyrochlore chemically modified electrode has been reported. Caffeine acts as an antagonist of adenosine A1 receptors (A1R) and A2AR at non-toxic doses. Chronic consumption of caffeine is reported to prevent the memory impairment in type 2 diabetic mice.

SAFETY INFORMATION

Signal Word

Warning

P301 + P312 + P330

RIDADRRIDADR

WGK Germany

WGK 1

Flash Point (F)

Not applicable

Flash Point (C)

Not applicable

Target Organs

Risk Statement

Supplemental Hazard Statements

DOCUMENTATION

Certificate of Analysis View Sample COA
Certificate of Origin

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